Pramod P Reddy, MBBS
Disclosures: Nothing to disclose
PHS 398/2590 (Rev. 06/09), Biographical Sketch Format Page

Program Director/Principal Investigator (Last, First, Middle):              Devarajan, Prasad

BIOGRAPHICAL SKETCH

Provide the following information for the Senior/key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person. DO NOT EXCEED FOUR PAGES.

 

NAME

Pramod P. Reddy, MD

POSITION TITLE

Professor of Clinical Surgery

University of Cincinnati, College of Medicine

eRA COMMONS USER NAME (credential, e.g., agency login)

Preddy

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

MM/YY

FIELD OF STUDY

Nrupatunga Junior College, Hyderabad, A.P. India

Intermediate Certificate

1980-1982

Biology, Physics and Chemistry

Siddhartha Medical College, Vijayawada. University of Health Sciences, Vijayawada, A.P., India.

(Transferred Credits forwards M.B.B.S.)

1982-1987

Medicine

Guntur Medical College, Guntur

University of Health Sciences, Vijayawada, A.P., India

M.B.B.S.

1987

Medicine

Albany Medical Center Hospital, Albany, NY. (Department of General Surgery)

Residency (PGY1 & 2)

1990-1992

General Surgery

Albany Medical Center Hospital, Albany, NY. (Department of Physiology & Cell Biology)

Post-Doctoral Research Fellowship

1992-1994

Physiology and Cell Biology

Albany Medical Center Hospital, Albany, NY. (Department of Urology)

Residency (PGY 3-5)

1994-1997

Urology

The Hospital for Sick Children, Toronto, Ontario, Canada.

Fellowship

1997-1999

Pediatric Urology

PHS 398/2590 (Rev. 06/09)              Page                   Biographical Sketch Format Page


Program Director/Principal Investigator (Last, First, Middle):              Devarajan, Prasad

 

A.              Personal Statement

The Division of pediatric urology at Cincinnati Children’s Hospital Medical Center is known for the care that we provide to children with complex congenital and acquired genitourinary conditions.  I am committed to becoming one of my specialty’s leaders in the management of these children.  I have developed particular expertise in the prenatal and postnatal care and treatment of children born with posterior urethral valves (PUV).  I am aware that in order to make a significant impact on a specific disease condition, the research strategy has to have a strong foundation in basic and translational science coupled with clinical expertise.  I have been building on my research experience that began in 1992 as a post-doctoral fellow in cell biology and included a K08 award to study bladder organogenesis.

The proposed application seeks to study the molecular basis of bladder dysfunction that is often seen in children with PUV, and to use the knowledge to create a clinical phenotype and risk stratification system for these patients.  Such a system will enable us to improve the care and clinical outcomes of patients with PUV.  The third project in this application involves the creation of a learning network to reduce variation of care and cost of caring for patients with PUV while optimizing their care.

 

Positions and Employment

              1990-1992                            Intern (PGY1) and Resident (PGY2),  General Surgery, Albany Medical Center Hospital, Albany, NY.  Chairman – Robert Leather, MD.  Non-Tenured Full Time.

              1992-1994                            Post-Doctoral Research Fellowship,  Dept of Physiology & Cell Biology, Albany Medical College, Albany, NY.  (Supported by NIH Grant No. T32-HL-07529). 

                                                                      Chairman – Thomas Saba, PhD.  Non-Tenured Full Time.             

              1994-1997                            Resident (PGY 3-5),  Urology,  Albany Medical Center Hospital, Albany, NY

                                                                      Chairman – James Mandell, MD.  Non-Tenured Full Time.

1997-1999              Fellow (PGY 6-7),  Pediatric Urology, The Hospital for Sick Children, Toronto, Canada.

                            Chairman – Antoine E. Khoury, MD.  Non-Tenured Full Time.             

              1999-2001                            Assistant Professor of Urology and Pediatrics,  University of Arkansas for Medical Sciences.  Little Rock, Arkansas. Chairman – Alex Finkbeiner, MD.  Non-Tenured Full Time Faculty.

              1999-2001                            Chief, Division of Pediatric Urology, Arkansas Children’s Hospital, Little Rock, Arkansas.  Medical Director – Betty Lowe, MD.  Non-Tenured Full Time.             

              2001-2005                            Assistant Professor of Surgery (Urology), University of Cincinnati, Cincinnati, Ohio.  Chairman – Jeffrey Matthews, MD, Chief – Donovan, MD.  Non-Tenured Full Time Faculty.                                                                     

              2001-2005                            Assistant Professor of Surgery (Pediatric Urology),  Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio.  Chairman – Richard Azizkhan, MD, Chief – Curtis A. Sheldon, MD.  Non-Tenured Full Time Faculty.             

              2005-2010                            Associate Professor of Clinical Surgery (Urology), University of Cincinnati, Cincinnati, Ohio.  Chairman – Jeffrey Matthews, MD, Chief – Donovan, MD.  Non-Tenured Full Time Faculty.                                                                     

              2005-2010                            Associate Professor of Clinical Surgery (Pediatric Urology),  Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio.  Chairman – Richard Azizkhan, MD, Chief – Curtis A. Sheldon, MD (as of July 2010 – I have been the acting Chief of Pediatric Urology).  Non-Tenured Full Time Faculty.             

              2010-2016                            Professor of Clinical Surgery (Pediatric Urology),  Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio.  Chairman – Richard Azizkhan, MD, Chief –Pramod P. Reddy.  Non-Tenured Full Time Faculty.             

Honors

              1983              Distinction in Biochemistry.  (Nagarjuna University, A.P., India).             

              1987              Vijay Pharma & Medical Equipment’s Gold Medal for Excellence in Medicine.

              1989              Honors in Urology, Albany Medical College.

              1993              Elected to the New York Academy of Sciences.

              1993              National Research Service Award.

              1994              National Research Service Award.

              1996              First Prize, Resident Essay Award. Awarded at the 48th Annual meeting of the Northeastern Section of the A.U.A. Buffalo, Sept, 1996. 

              1996              Honorable mention, Resident Poster/Essay Award.  Awarded at the 14th World Congress on Endourology and SWL, November 1996, Melbourne, Australia.

              1996              Silver Scalpel Award, Albany Medical College for Excellence in Surgical Education.

              1997              The Pfizer Scholars in Urology Award.

              1997              Honorable Mention, Upstate New York Urological Association’s 2nd Annual Residents’ Day Competition.

              1999              Second Prize, Surgical Services Clinical Research Contest. The Hospital for Sick Children, Toronto, Canada.

              1999              First Prize, Basic Science Research Prize, American Academy of Pediatrics Section of Pediatric Urology. (Sponsored by the American Association of Pediatric Urologists).             

              2007              AUA Foundation/NIDDK/NCI Surgeon/Scientist award

 

  1. Selected Peer-reviewed Publications (Selected from 53 peer-reviewed publications)

Most relevant to the current application

  1. Reddy PP, Das AK, Rao NC, Kim S, Mandell J.  Quality of life improvement in patients undergoing complex lower urinary tract reconstruction for neuropathic bladder dysfunction: an outcome analysis.  Surg Forum. 1997;48:628.
  2. Calvano CJ, Reddy PP, Moran ME, Boyle KE, Housley HT, Jennings RW, Harrison MR, Mandell J.  Initial studies of holmium:YAG laser creation of spinal defects in fetal rabbits: model for urologic effects of myelomeningocele.  J Endourol. 1998 Apr;12(2):199-203.
  3. Barrieras D, Lapointe S, Reddy PP, Williot P, McLorie GA, Bagli D, Khoury AE, Merguerian PA.  Urinary retention after bilateral extravesical ureteral reimplantation: does dissection distal to the ureteral orifice have a role?  J Urol. 1999 Sep;162(3 Pt 2):1197-200.
  4. Reddy PP, Barrieras DJ, Wilson G, Bagli DJ, McLorie GA, Khoury AE, Merguerian PA.  Regeneration of functional bladder substitutes using large segment acellular matrix allografts in a porcine model.  J Urol. 2000 Sep;164(3 Pt 2):936-41.
  5. Merguerian PA, Reddy PP, Barrieras DJ, Wilson GJ, Woodhouse K, Bagli DJ, McLorie GA, Khoury AE.  Acellular bladder matrix allografts in the regeneration of functional bladders: evaluation of large-segment (> 24 cm) substitution in a porcine model.  BJU Int. 2000 May;85(7):894-8.
  6. Capolicchio G, Aitken KJ, Gu JX, Reddy P, Bagli DJ.  Extracellular matrix gene responses in a novel ex vivo model of bladder stretch injury.  J Urol. 2001 Jun;165(6 Pt 2):2235-40.
  7. Reddy PP, Redman JF.  The Management of Childhood Voiding Dysfunction.  J Ark Med Soc. 2003 Mar;99(9):295-98.
  8. Ellsworth PI, Borgstein NG, Nijman RJM, and Reddy PP.  Use of Tolterodine in Children With Neurogenic Detrusor Overactivity: Relationship Between Dose and Urodynamic Response. J. Urol Vol 174(4 Pt 2):1647-51 Oct 2005.
  9. Kitchens DM, DeFoor WR, Minevich E, Reddy PP, Sheldon CA, and Koyle M.  Incontinence following bladder neck reconstruction: Is there a role for endoscopic management? J. Urol Vol 177(1):302-5; discussion 305-6. Jan 2007.
  10. DeFoor WR, Minevich E, Reddy PP, Sheldon CA, Koyle M.  Long Term Outcomes of The Neobladder in Pediatric Continent Urinary Reconstruction.  J. Urol, 181:2689-94, 2009.

Additional recent publications of importance to the field (in chronological order)

  1. Reddy PP, Kaufman, RP, McCandless BK, Neuman PH, Malik AB.  Thrombin-Induced expression of neutrophil (PMN) CD18 Integrin: A mechanism for intrarenal PMN sequestration. Surg Forum.  1993; 44:767-70.
  2. Brien TP, Reddy PP, Vincent PA, Lewis EP, Ross JS, Saba TM.  Lung matrix deposition of normal and alkylated plasma fibronectin: response to postsurgical sepsis.  Am J Physiol. 1998 Mar;274(3 Pt 1):L432-43.

D.              Research Support

Completed Research Support

1K08 DK069608-01                                                                                                                                            Reddy (PI)                                                                      2/2005 -2/2010

This was a K08 training grant.  The goal of this study was to assess the molecular basis of normal bladder organogenesis using a Xenopus laevis animal model.

Role: PI

 

              AUA Foundation/NIDDK Surgeon/Scientist award                  Reddy (PI)                                                         2/2007 – 2/2010

The goal of this study was to assess the molecular basis of normal bladder organogenesis, specifically looking at th role of Sonic Hedgehog in transforming the hindgut into bladder using a Xenopus laevis animal model.

Role: PI

 

PHS 398/2590 (Rev. 06/09)              Page   1                Continuation Format Page